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Review
. 2007 Sep;21(5):255-65.
doi: 10.1016/j.blre.2007.01.002. Epub 2007 Mar 26.

Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma

S Vincent Rajkumar  1 , Martha Q Lacy, Robert A Kyle
Affiliations
Review

Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma

S Vincent Rajkumar et al. Blood Rev. 2007 Sep.

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow in the absence of end-organ damage. Updated diagnostic criteria for these disorders, risk-stratification models to determine prognosis, and the current management of these two entities are discussed in this review.

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