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Randomized Controlled Trial
. 2007 Mar-Apr;14(2):184-8.
doi: 10.1016/j.jmig.2006.09.016.

Oxytocin infusion in laparoscopic myomectomy may decrease operative blood loss

Chin-Jung Wang  1 , Chyi-Long Lee, Leung-To Yuen, Nari Kay, Chien-Min Han, Yung-Kuei Soong
Affiliations
Randomized Controlled Trial

Oxytocin infusion in laparoscopic myomectomy may decrease operative blood loss

Chin-Jung Wang et al. J Minim Invasive Gynecol. 2007 Mar-Apr.

Abstract

Study objective: To evaluate the influence of oxytocin on operative blood loss during laparoscopic myomectomy (LM).

Design: Prospective clinical study (Canadian Task Force classification I).

Setting: Tertiary care university hospital.

Patients: Sixty women scheduled for myomectomy because of symptomatic uterine myomas.

Intervention: Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LM.

Measurements and main results: Blood loss and blood transfusion rate were significantly greater in the group without oxytocin infusion (group B) than in the group with oxytocin infusion (group A), with 445.0 +/- 268.6 mL (95% CI 344.7-545.3) versus 269.5 +/- 225.8 mL (95% CI 185.2-353.8)/(p <.05), and 36.7% versus 6.7% (p <.05), respectively. There was no significant difference in average age, body weight, or numbers of vaginal delivery and cesarean sections between the 2 groups. There was no significant difference in mean total myoma weight, main myoma size, postoperative stay, and complications between the 2 groups.

Conclusion: Oxytocin infusion combined with skillful surgical techniques may decrease operative blood loss and blood transfusion during LM.

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