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. 2007 Aug;133(8):519-24.
doi: 10.1007/s00432-007-0196-y. Epub 2007 Mar 17.

Serum level of arginine-vasopressin influences the prognosis of extensive-disease small-cell lung cancer

Shigeki Umemura  1 , Yoshihiko Segawa, Hiroshi Ueoka, Katsuyuki Hotta, Katsuyuki Kiura, Nagio Takigawa, Masahiro Tabata, Akihiro Bessho, Tetsu Shinkai, Mitsune Tanimoto
Affiliations

Serum level of arginine-vasopressin influences the prognosis of extensive-disease small-cell lung cancer

Shigeki Umemura et al. J Cancer Res Clin Oncol. 2007 Aug.

Abstract

Purpose: The purpose of this study is to elucidate the influence of serum arginine-vasopressin (AVP) level on prognosis of extensive-disease small-cell lung cancer (ED-SCLC).

Methods: We retrospectively investigated the clinical records of 163 patients with ED-SCLC, who were admitted to Okayama University Hospital or National Shikoku Cancer Center Hospital. The influence of 14 pretreatment variables on survival was analyzed.

Results: In a multivariate analysis of 163 patients, elevation of serum LDH level (P = 0.028) and poor performance status (PS > or = 2, P = 0.002) were independent poor prognostic factors. In 34 patients whose serum AVP levels were available, high serum AVP level was related to the poor prognosis (P < 0.001). The serum-sodium level did not affect the survival. Median serum level of osmotic pressure in 34 patients was normal (284.9 mOsm/kg), although, serum osmotic pressure was low in four of six patients with high serum AVP level. In all patients with high serum AVP level, serum LDH level was elevated.

Conclusions: The data from the current study suggested that serum LDH level and PS were the poor prognostic factors for ED-SCLC. But we additionally identified the prognostic significance of serum AVP level, which may be a more useful factor than serum-sodium level.

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Figures

Fig. 1
Fig. 1
Overall survival of patients with ED-SCLC according to serum-sodium level (≥135 mEq/l, n = 141; solid line versus <135 mEq/l, n = 22; dotted line)
Fig. 2
Fig. 2
The correlation of serum AVP level with plasma osmotic pressure (n = 34)
Fig. 3
Fig. 3
Overall survival of patients with ED-SCLC according to serum AVP level (≤6.3 pg/ml, n = 28; solid line versus >6.3 pg/ml, n = 6; dotted line)
See this image and copyright information in PMC

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