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. 2007 Jan;13(1):18-24.
doi: 10.3201/eid1301.060910.

Prevalence of G2P[4] and G12P[6] rotavirus, Bangladesh

Mustafizur Rahman  1 , Rasheda Sultana, Giasuddin Ahmed, Sharifun Nahar, Zahid M Hassan, Farjana Saiada, Goutam Podder, Abu S G Faruque, A K Siddique, David A Sack, Jelle Matthijnssens, Marc Van Ranst, Tasnim Azim
Affiliations

Prevalence of G2P[4] and G12P[6] rotavirus, Bangladesh

Mustafizur Rahman et al. Emerg Infect Dis. 2007 Jan.

Abstract

Approximately 20,000 stool specimens from patients with diarrhea visiting 1 urban and 1 rural hospital in Bangladesh during January 2001-May 2006 were tested for group A rotavirus antigen, and 4,712 (24.0%) were positive. G and P genotyping was performed on a subset of 10% of the positive samples (n = 471). During the 2001-2005 rotavirus seasons, G1P[8] (36.4%) and G9P[8] (27.7%) were the dominant strains, but G2[4] and G12P[6] were present in 15.4% and 3.1% of the rotavirus-positive patients, respectively. During the 2005-06 rotavirus season, G2P[4] (43.2%) appeared as the most prevalent strain, and G12P[6] became a more prevalent strain (11.1%) during this season. Because recently licensed rotavirus vaccines include only the P[8] specificity, it is unknown how the vaccines will perform in settings where non-P[8] types are prevalent.

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Figures

Figure 1
Figure 1
Age distribution for rotavirus-positive patients, Bangladesh, 2001–2005.
Figure 2
Figure 2
Distribution of rotavirus-positive patients by month, Dhaka and Matlab, Bangladesh. Percentages of positive rotavirus patients were calculated based on all diarrhea patients admitted to the Dhaka and Matlab hospital surveillance system during 2001–2005. The years are shown with different colored lines. The thick brown line represents the average for all years.
Figure 3
Figure 3
Correlation between cases of rotavirus diarrhea and air temperature and water level in Dhaka, Bangladesh, January 2001–May 2005.
Figure 4
Figure 4
Temporal changes of the distribution of major rotavirus genotypes in Bangladesh, 2001–2006.
See this image and copyright information in PMC

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