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. 2007 Jun;51(6):2244-6.
doi: 10.1128/AAC.00229-07. Epub 2007 Mar 19.

Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida

Corinna Kehrenberg  1 , Stefan Schwarz
Affiliations

Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida

Corinna Kehrenberg et al. Antimicrob Agents Chemother. 2007 Jun.

Abstract

Pasteurella multocida isolates with high-level spectinomycin resistance in which no adenyltransferase genes could be demonstrated exhibited a C1192G transversion in the 16S rRNA of all six or five of the six rRNA operons and/or two different types of 3-bp deletions in the rpsE gene that codes for the ribosomal protein S5.

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Figures

FIG. 1.
FIG. 1.
(a) Secondary structure of 16S rRNA with the site of mutation in helix 34 depicted in detail. (b) Nucleotide and amino acid alignment of the 5′ ends of the rpsE genes and the corresponding amino acid sequences of ribosomal proteins S5 of the three representative P. multocida isolates 1, 9, and 13. Amino acids are given in the single-letter code. Boxes and boldface type indicate the altered regions.
See this image and copyright information in PMC

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