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Review
. 2006;29(3):193-8.

Cancer risk associated with alcohol and tobacco use: focus on upper aero-digestive tract and liver

Claudio Pelucchi  1 , Silvano Gallus, Werner Garavello, Cristina Bosetti, Carlo La Vecchia
Affiliations
Review

Cancer risk associated with alcohol and tobacco use: focus on upper aero-digestive tract and liver

Claudio Pelucchi et al. Alcohol Res Health. 2006.

Abstract

Alcohol and tobacco, alone or in combination, are associated with an increased risk of various cancers, including those of the upper aero-digestive tract and liver. Both alcohol and tobacco use can increase the risk of cancer of the oral cavity and throat (pharynx, and their combined use has a multiplicative effect on risk. Moreover, those regions of the mouth and pharynx that are more directly exposed to alcohol or tobacco are more likely to be affected by cancer than other regions. A similar effect was found with respect to cancer of the voice box (larynx). For squamous cell carcinoma of the esophagus, alcohol and tobacco also appear to increase risk synergistically. With liver cancer, in contrast, alcohol consumption and tobaacco use appear to be independent risk factors.

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Conflict of interest statement

Financial Disclosure

The authors declare that they have no competing financial interests.

Figures

None
Anatomy of the upper aero-digestive tract.
See this image and copyright information in PMC

References

    1. Altieri A, Garavello W, Bosetti C, et al. Alcohol consumption and risk of laryngeal cancer. Oral Oncology. 2005;41:956–965. - PubMed
    1. Bagnardi V, Blangiardo M, La Vecchia C, Corrao G. A meta-analysis of alcohol drinking and cancer risk. British Journal of Cancer. 2001;85:1700–1705. - PMC - PubMed
    1. Blot WJ, McLaughlin JK, Winn DM, et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Research. 1988;48:3282–3287. - PubMed
    1. Boffetta P, Hashibe M. Alcohol and cancer. Lancet Oncology. 2006;7:149–156. - PubMed
    1. Bosetti C, Negri E, Franceschi S, et al. Risk factors for oral and pharyngeal cancer in women: A study from Italy and Switzerland. British Journal of Cancer. 2000;82:204–207. - PMC - PubMed

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