Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Feb 21;13(7):1135-7.
doi: 10.3748/wjg.v13.i7.1135.

Pancreatic metastasis of leiomyosarcoma in the right thigh: a case report

Yang-Seok Koh  1 , Jung Chul, Chol-Kyoon Cho, Hyun-Jong Kim
Affiliations
Review

Pancreatic metastasis of leiomyosarcoma in the right thigh: a case report

Yang-Seok Koh et al. World J Gastroenterol. .

Abstract

Pancreatic tumors are primary in most of the cases. Pancreatic metastases associated with other primary malignancies, especially pancreatic metastasis of leiomyosarcoma, are uncommon. A 66-year-old woman underwent surgical resection of malignant mesenchymoma (70% osteosarcoma and 30% leiomyosarcoma) in the right thigh. In the postoperative period, a pancreatic mass was identified radiologically by abdominal computed tomography. Pylorus-preserving pancreaticoduodenectomy was performed. The surgical specimen revealed leiomyosarcoma metastasized to the pancreas. A metastatic nodule on the remnant pancreatic tail was discovered 9 mo after the first pancreatic resection, and distal pancreatectomy was performed. Cases of pancreatic metastasis from leiomyosarcoma are extremely rare, especially when the tumor was resectable. We report here a unique case of pancreatic metastasis from a leiomyosarcoma in the right thigh that had been treated surgically.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Radiological findings. A: Gadolinium-enhanced T1 weighted image showing a soft tissue tumor in the muscle of the anterior thigh; B: Contrast-enhanced abdominal CT scan showing a heterogeneously enhanced mass at the head of the pancreas; C: Gadolinium-enhanced T1 weighted image showing a well-enhanced mass with necrotic foci at the head of the pancreas; D: Follow-up CT obtained after 10 mo showing a low attenuated mass in the tail of the pancreas.
Figure 2
Figure 2
Gross and microscopic findings for metastatic leiomyo-sarcoma. A: The section reveals a whitish solid tumor with a lobulated pattern and a yellowish necrotic portion, abutting duodenal wall on the left side, and compressed pancreatic head tissue on the right side; B: Low-power view displaying eosinophilic intersecting fascicles circumscribed by a fibrous capsule (a) and adjacent normal pancreatic tissue (b) (hematoxylin and eosin stain ×40); C: Cellular proliferation of atypical spindle tumor cells is accompanied by nuclear atypia and hyperchromasia (hematoxylin and eosin stain × 200); D: Tumor cells show immunoreactivity for desmin.
See this image and copyright information in PMC

References

    1. Crippa S, Angelini C, Mussi C, Bonardi C, Romano F, Sartori P, Uggeri F, Bovo G. Surgical treatment of metastatic tumors to the pancreas: a single center experience and review of the literature. World J Surg. 2006;30:1536–1542. - PubMed
    1. Adsay NV, Andea A, Basturk O, Kilinc N, Nassar H, Cheng JD. Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature. Virchows Arch. 2004;444:527–535. - PubMed
    1. Sperti C, Pasquali C, Liessi G, Pinciroli L, Decet G, Pedrazzoli S. Pancreatic resection for metastatic tumors to the pancreas. J Surg Oncol. 2003;83:161–166; discussion 166. - PubMed
    1. Roland CF, van Heerden JA. Nonpancreatic primary tumors with metastasis to the pancreas. Surg Gynecol Obstet. 1989;168:345–347. - PubMed
    1. Hiotis SP, Klimstra DS, Conlon KC, Brennan MF. Results after pancreatic resection for metastatic lesions. Ann Surg Oncol. 2002;9:675–679. - PubMed