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. 2008;21(1):112-4.
doi: 10.1016/j.pupt.2007.01.003. Epub 2007 Feb 12.

Plasma serotonin levels are normal in pulmonary arterial hypertension

David J Lederer  1 , Evelyn M Horn, Erika B Rosenzweig, Wahida Karmally, Megan Jahnes, Robyn J Barst, Steven M Kawut
Affiliations

Plasma serotonin levels are normal in pulmonary arterial hypertension

David J Lederer et al. Pulm Pharmacol Ther. 2008.

Abstract

Serotonin (5-HT) has been implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We hypothesized that plasma 5-HT would be elevated in PAH related to associated conditions. We performed a prospective cohort study of 21 patients with PAH undergoing initial right heart catheterization and 6 healthy controls. Platelet-free plasma 5-HT levels were similar in patients with idiopathic PAH, PAH related to associated conditions, and healthy controls. Higher 5-HT levels correlated with increased six-minute walk distance (r=0.55, p=0.04). These data suggest that plasma 5-HT levels are normal in PAH. Plasma 5-HT may therefore not be a useful biomarker in this condition.

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Figures

Figure 1
Figure 1
Platelet-free plasma serotonin levels for IPAH, APAH, and controls: median (line) and interquartile range (box). Whiskers are 1.5x the interquartile range. Filled circles are outliers.
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