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Review
. 2007 May 7;96(9):1320-3.
doi: 10.1038/sj.bjc.6603695. Epub 2007 Mar 20.

Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer

M Stanley  1
Affiliations
Review

Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer

M Stanley. Br J Cancer. .

Abstract

Virtually all cases of cervical cancer and its precursor intra-epithelial lesions are a result of infection with one or other of a subset of genital human papillomaviruses (HPVs), suggesting that prevention of HPV infection by prophylactic vaccination would be a highly effective anticancer strategy. Two HPV L1 virus-like particle vaccines have been developed, a quadrivalent HPV16/18/6/11 product and a bivalent HPV16/18 product; both have been shown to be highly immunogenic with a good safety profile and 100% efficacy against HPV16/18-related high-grade cervical intra-epithelial neoplasia (CIN2/3), implying that they will be effective at preventing HPV16/18-related cervical cancer.

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