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. 2007 Apr 23;96(8):1234-6.
doi: 10.1038/sj.bjc.6603693. Epub 2007 Mar 20.

The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

S Bulk  1 , J Berkhof, L Rozendaal, N C Fransen Daalmeijer, M Gök, F A de Schipper, F J van Kemenade, P J F Snijders, C J L M Meijer
Affiliations

The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

S Bulk et al. Br J Cancer. .

Abstract

In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.

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References

    1. Berkhof J, Bulkmans NW, Bleeker MCG, Bulk S, Snijders PJF, Voorhorst FJ, Meijer CJLM (2006) HPV type-specific 18-month risk of high-grade cervical intraepithelial neoplasia in women with a normal or borderline/mildly dyskaryotic smear. Cancer Epidemiol Biomarkers Prev 15: 1268–1273 - PubMed
    1. Bulk S, Berkhof J, Bulkmans NW, Zielinski GD, Rozendaal L, van Kemenade FJ, Snijders PJ, Meijer CJ (2006) Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands. Br J Cancer 94: 171–175 - PMC - PubMed
    1. Bulkmans NW, Bleeker MC, Berkhof J, Voorhorst FJ, Snijders PJ, Meijer CJ (2005) Prevalence of types 16 and 33 is increased in high-risk human papillomavirus positive women with cervical intraepithelial neoplasia grade 2 or worse. Int J Cancer 117: 177–181 - PubMed
    1. Castle PE, Solomon D, Schiffman M, Wheeler CM (2005) Human papillomavirus type 16 infections and 2-year absolute risk of cervical precancer in women with equivocal or mild cytologic abnormalities. J Natl Cancer Inst 97: 1066–1071 - PubMed
    1. Clifford G, Franceschi S, Diaz M, Munoz N, Villa LL (2006) Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases. Vaccine 24Suppl 3: S26–S34 - PubMed

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