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Comment
. 2007 May;151(2):161-2.
doi: 10.1038/sj.bjp.0707164. Epub 2007 Mar 20.

Optimisation of anti-psychotic therapeutics: a balancing act?

A J Lawrence  1
Affiliations
Comment

Optimisation of anti-psychotic therapeutics: a balancing act?

A J Lawrence. Br J Pharmacol. 2007 May.

Abstract

Schizophrenia is a complex and debilitating disorder. Although effective therapeutic strategies are available, these are not without problems and are not universally efficacious. In this issue of the British Journal of Pharmacology, a trio of papers describe the characterisation of a potential, novel anti-psychotic medication, F15063. This compound combines antagonism of dopamine D(2)-like receptors with agonism at 5-HT(1A) receptors. Based on in vitro and in vivo profiles, the authors suggest that this compound approaches the 'optimal balance' for activity at these receptor systems.

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References

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