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. 2007 Jun;45(6):2002-4.
doi: 10.1128/JCM.00104-07. Epub 2007 Mar 21.

Molecular epidemiology of the sil streptococcal invasive locus in group A streptococci causing invasive infections in French children

Philippe Bidet  1 , Céline Courroux, Christophe Salgueiro, Agnès Carol, Patricia Mariani-Kurkdjian, Stéphane Bonacorsi, Edouard Bingen
Affiliations

Molecular epidemiology of the sil streptococcal invasive locus in group A streptococci causing invasive infections in French children

Philippe Bidet et al. J Clin Microbiol. 2007 Jun.

Abstract

We found 31 different emm-toxin genotypes among 74 group A streptococcal isolates causing invasive infections in French children. The predominant emm types were emm1 (25%), emm3 (8%), emm4 (8%), emm6 (7%), and emm89 (9%). Sixteen percent of isolates harbored the streptococcal invasive locus, half of them belonging to emm4.

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Figures

FIG. 1.
FIG. 1.
Comparison of the sil loci in the three reference strains J95 (M14), MGAS8232 (M18), and MGAS10750 (M4). Each ORF is represented by a broad arrow and a number or gene name. The hatched arrow represents the inactivated silCR ORF in J95 (corresponding to ORF 540 in MGAS8232 and ORF 405 in MGAS10750). The gray arrows represent the potential silC coding sequence in MGAS8232 and MGAS10750. Below each ORF, the annotation is given if it differs from the hypothetical protein.
See this image and copyright information in PMC

Comment in

References

    1. Beall, B., R. Facklam, and T. Thompson. 1996. Sequencing emm-specific PCR products for routine and accurate typing of group A streptococci. J. Clin. Microbiol. 34:953-958. - PMC - PubMed
    1. Beres, S. B., E. W. Richter, M. J. Nagiec, P. Sumby, S. F. Porcella, F. R. DeLeo, and J. M. Musser. 2006. Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus. Proc. Natl. Acad. Sci. USA 103:7059-7064. - PMC - PubMed
    1. Beres, S. B., G. L. Sylva, K. D. Barbian, B. Lei, J. S. Hoff, N. D. Mammarella, M. Y. Liu, J. C. Smoot, S. F. Porcella, L. D. Parkins, D. S. Campbell, T. M. Smith, J. K. McCormick, D. Y. Leung, P. M. Schlievert, and J. M. Musser. 2002. Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence. Proc. Natl. Acad. Sci. USA 99:10078-10083. - PMC - PubMed
    1. Cleary, P. P., E. L. Kaplan, J. P. Handley, A. Wlazlo, M. H. Kim, A. R. Hauser, and P. M. Schlievert. 1992. Clonal basis for resurgence of serious Streptococcus pyogenes disease in the 1980s. Lancet 339:518-521. - PubMed
    1. Cunningham, M. W. 2000. Pathogenesis of group A streptococcal infections. Clin. Microbiol. Rev. 13:470-511. - PMC - PubMed

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