[Post-transplantation diabetes mellitus]
- PMID: 17378145
[Post-transplantation diabetes mellitus]
Abstract
Post-transplant diabetes mellitus is a frequent and serious complication after organ transplantation. Its ethiopathogenesis is complex, with interaction between intrinsic factors (older age, body mass index, individual and family history, hepatitis C virus infection) and graft related factors (immunosuppressive regimen, HLA status). In kidney transplant recipients, new onset diabetes mellitus is associated with an adverse effect upon patient survival, with an increased incidence of infectious and cardiovascular complications. Furthemore, post transplant diabetes mellitus clearly affects long-term allograft survival. Management of new onset diabetes mellitus after transplantation includes: screening for risk factors before transplantation (to propose lifestyle modifications and adaptation of immunosuppressive therapy); regular monitoring of glycemia after transplantation; non pharmacologic and pharmacologic therapies associated with management of others cardiovascular risk factors (hypertension, dyslipidemias).
Similar articles
-
New-onset diabetes after transplantation.J Heart Lung Transplant. 2004 May;23(5 Suppl):S194-201. doi: 10.1016/j.healun.2004.03.007. J Heart Lung Transplant. 2004. PMID: 15093805 Review.
-
Post-transplant diabetes mellitus.J Nephrol. 2003 Sep-Oct;16(5):626-34. J Nephrol. 2003. PMID: 14733407 Review.
-
Clinicoepidemiologic study of posttransplant diabetes after living-donor renal transplant.Exp Clin Transplant. 2008 Mar;6(1):42-7. Exp Clin Transplant. 2008. PMID: 18405244
-
Post transplantation diabetes mellitus in kidney allograft recipients: current concepts.Saudi J Kidney Dis Transpl. 2008 Nov;19(6):904-10. Saudi J Kidney Dis Transpl. 2008. PMID: 18974574
-
New-onset diabetes mellitus after solid organ transplantation.Transpl Int. 2009 May;22(5):519-30. doi: 10.1111/j.1432-2277.2008.00800.x. Epub 2008 Nov 20. Transpl Int. 2009. PMID: 19040489 Review.
Cited by
-
OGTT 2-hour serum C-peptide index as a predictor of post-transplant diabetes mellitus in kidney transplant recipients.Ann Transl Med. 2019 Oct;7(20):538. doi: 10.21037/atm.2019.10.14. Ann Transl Med. 2019. PMID: 31807520 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Medical
Research Materials