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. 2007 May;70(5):846-8.
doi: 10.1021/np060472c. Epub 2007 Mar 23.

Eurysterols A and B, cytotoxic and antifungal steroidal sulfates from a marine sponge of the genus Euryspongia

Chollaratt Boonlarppradab  1 , D John Faulkner
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Eurysterols A and B, cytotoxic and antifungal steroidal sulfates from a marine sponge of the genus Euryspongia

Chollaratt Boonlarppradab et al. J Nat Prod. 2007 May.

Abstract

Two new steroidal sulfates, eurysterols A (1) and B (2), were isolated from an undescribed marine sponge of the genus Euryspongia collected in Palau. The structures of the new compounds were assigned by NMR spectroscopic data interpretation. Compounds 1 and 2 showed cytotoxicity against human colon carcinoma (HCT-116) cells with IC50 values of 2.9 and 14.3 microg/mL, respectively, and exhibited antifungal activity against amphotericin B-resistant and wild-type strains of Candida albicans with MIC values, in turn, of 15.6 and 62.5 microg/mL.

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