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Review
. 2007 Jun-Jul;89(6-7):754-60.
doi: 10.1016/j.biochi.2007.01.013. Epub 2007 Feb 20.

Triggering antiviral response by RIG-I-related RNA helicases

Takashi Fujita  1 , Kazuhide Onoguchi, Koji Onomoto, Reiko Hirai, Mitsutoshi Yoneyama
Affiliations
Review

Triggering antiviral response by RIG-I-related RNA helicases

Takashi Fujita et al. Biochimie. 2007 Jun-Jul.

Abstract

TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses.

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