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. 1992 Mar;66(3):1799-803.
doi: 10.1128/JVI.66.3.1799-1803.1992.

Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41

W R Lee  1 , X F Yu, W J Syu, M Essex, T H Lee
Affiliations

Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41

W R Lee et al. J Virol. 1992 Mar.

Abstract

Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the possibility that N-linked sugars at this site may have an important role in the human immunodeficiency virus type 1 life cycle.

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References

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