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Comment
. 2007 Mar 23;128(6):1027-8.
doi: 10.1016/j.cell.2007.02.033.

Argonautes and company: sailing against the wind

Suvendra N Bhattacharyya  1 , Witold Filipowicz
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Argonautes and company: sailing against the wind

Suvendra N Bhattacharyya et al. Cell. .
Free article

Abstract

The 3'-untranslated region (UTR) of mRNA is crucial for posttranscriptional regulation. In this issue, Vasudevan and Steitz (2007) report a new function for AGO2 and FXR1--two proteins that have been linked to the regulation of microRNAs and translation repression. AGO2 and FXR1 bind to the AU-rich element in the 3'-UTR of TNFalpha mRNA, unexpectedly activating its translation in a cell growth-dependent manner.

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