Comment
doi: 10.1016/j.cell.2007.02.033.
Argonautes and company: sailing against the wind
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- PMID: 17382873
- DOI: 10.1016/j.cell.2007.02.033
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Comment
Argonautes and company: sailing against the wind
Cell.
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Free article
Abstract
The 3'-untranslated region (UTR) of mRNA is crucial for posttranscriptional regulation. In this issue, Vasudevan and Steitz (2007) report a new function for AGO2 and FXR1--two proteins that have been linked to the regulation of microRNAs and translation repression. AGO2 and FXR1 bind to the AU-rich element in the 3'-UTR of TNFalpha mRNA, unexpectedly activating its translation in a cell growth-dependent manner.
Comment on
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AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.Cell. 2007 Mar 23;128(6):1105-18. doi: 10.1016/j.cell.2007.01.038. Cell. 2007. PMID: 17382880 Free PMC article.
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