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Comment
. 2007 Mar 23;128(6):1029-30.
doi: 10.1016/j.cell.2007.02.034.

SCOPing out proteases in long-term memory

Vadim Y Bolshakov  1
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SCOPing out proteases in long-term memory

Vadim Y Bolshakov. Cell. .
Free article

Abstract

The ERK1/2 MAP kinase (MAPK) signaling pathway is important for the formation of long-term memories. In this issue, Shimizu et al. (2007) provide new insight into the regulation of this pathway by demonstrating that activation of MAP kinase occurs through the calcium-dependent degradation of SCOP (suprachiasmatic nucleus circadian oscillatory protein) by the protease calpain.

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