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Comment
. 2007 Mar 23;128(6):1035-6.
doi: 10.1016/j.cell.2007.03.002.

A Bcl-xL timer sets platelet life span

Bing Qi  1 , J Marie Hardwick
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A Bcl-xL timer sets platelet life span

Bing Qi et al. Cell. .
Free article

Abstract

Platelets are cell fragments lacking nuclei that play a key role in blood clotting. Using an impressive genetic screen involving ENU-mutagenesis of whole mice, Mason et al. (2007) report in this issue their identification of mutations in the antiapoptotic protein Bcl-x(L) that cause accelerated death of platelets leading to platelet deficiency.

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  • Programmed anuclear cell death delimits platelet life span.
    Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, Huang DC, Kile BT. Mason KD, et al. Cell. 2007 Mar 23;128(6):1173-86. doi: 10.1016/j.cell.2007.01.037. Cell. 2007. PMID: 17382885

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