Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 May;381(1):93-7.
doi: 10.1016/j.cca.2007.02.017. Epub 2007 Feb 20.

Enzymes and related proteins as cancer biomarkers: a proteomic approach

Shu-Ling Liang  1 , Daniel W Chan
Affiliations
Review

Enzymes and related proteins as cancer biomarkers: a proteomic approach

Shu-Ling Liang et al. Clin Chim Acta. 2007 May.

Abstract

Background: The discovery of cancer biomarkers has become a major focus of cancer research, which holds promising future for early detection, diagnosis, monitoring disease recurrence and therapeutic treatment efficacy to improve long-term survival of cancer patients. Most of the functional information of the cancer-associated genes resides in the proteome. Since cancer is a complex disease, it might require a panel of multiple biomarkers in order to achieve sufficient clinical efficacy.

Methods: Serum/plasma is the most accessible biological specimen collected from patients. Therefore, serum proteomic diagnostics would be the most promising new test for cancer. With the advent of new and improved proteomic technologies, such as protein chips and mass spectrometry coupled with advanced bioinformatic tools, it is possible to develop potential cancer biomarkers. However, specimen collection, handling, study design and data analysis are essential components for successful biomarker discovery and validation. Multi-center case control study should be conducted with extensive clinical validation to minimize the impact of possible confounding variables (non-biological).

Conclusions: Enzymes and related proteins, such as inhibitors, are promising candidates for cancer diagnostics.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Chan DW, Schwartz MK. Tumor markers: Introduction and general principles. In: Diamandis, Fritsche, Lilja, Chan, Schwzrtz, editors. Tumor markers: Physiology, patholbiology, technology and clinical applications. AACC Press; 2002. pp. 9–17.
    1. Chatterjee SK, Zetter BR. Cancer biomarkers: knowing the present and predicting the future. Future Oncol. 2005;1:37–50. - PubMed
    1. Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002;1:845–867. - PubMed
    2. McDonald WH, Yates JR., 3rd Shotgun proteomics and biomarker discovery. Dis Markers. 2002;18:99–105. - PMC - PubMed
    1. Colantonio DA, Chan DW. The clinical application of proteomics. Clin Chimica Acta. 2005;357:151–158. - PubMed
    1. Tirumalai RS, Chan KC, Prieto DA, Issaq HJ, Conrads TP, Veenstra TD. Characterization of the low molecular weight human serum proteome. Mol Cell Proteomics. 2003;2:1096–1103. - PubMed

Publication types

LinkOut - more resources