Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2007 Apr;24(4):276-80.
doi: 10.1136/emj.2006.043265.

Comparison of lactated Ringer's solution and 0.9% saline in the treatment of rhabdomyolysis induced by doxylamine intoxication

Young Soon Cho  1 , Hoon Lim, Seung Ho Kim
Affiliations
Randomized Controlled Trial

Comparison of lactated Ringer's solution and 0.9% saline in the treatment of rhabdomyolysis induced by doxylamine intoxication

Young Soon Cho et al. Emerg Med J. 2007 Apr.

Abstract

Objective: To compare the effectiveness and side effects of lactated Ringer's solution (LR) and 0.9% saline (NS) in the treatment of rhabdomyolysis induced by doxylamine intoxication.

Methods: In this 15-month-long prospective randomised single-blind study, after excluding 8 patients among 97 doxylamine-intoxicated patients, 28 (31%) patients were found to have developed rhabdomyolysis and were randomly allocated to NS group (n = 15) or LR group (n = 13).

Results: After 12 h of aggressive hydration (400 ml/h), urine/serum pH was found to be significantly higher in the LR group, and serum Na+/Cl- levels to be significantly higher in the NS group. There were no significant differences in serum K+ level and in the time taken for creatine kinase normalisation. The amount of sodium bicarbonate administered and the frequency administration of diuretics was significantly higher in the NS group. Unlike the NS group, the LR group needed little supplemental sodium bicarbonate and did not develop metabolic acidosis.

Conclusion: LR is more useful than NS in the treatment of rhabdomyolysis induced by doxylamine intoxication.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Choi O K, Yoo J Y, Kim M S.et al Acute drug intoxication in ED of urban area. J Korean Soc Emerg Med 19952324–329.
    1. Hampel G, Horstkotte H, Rumpf K W. Myoglobinuric renal failure due to drug‐induced rhabdomyolysis. Hum Toxicol 19832197–203. - PubMed
    1. Koppel C, Tenczer J, Ibe K. Poisoning with over‐the‐counter doxylamine preparation: an evaluation of 109 cases. Hum Toxicol 19876355–359. - PubMed
    1. Yoon C J, Oh J H, Goo H D.et al Clinical review of doxylamine succinate overdose. J Korean Soc Emerg Med 19989317–322.
    1. Frankel D, Dolgin J, Murray B M. Non traumatic rhabdomyolysis complicating antihistamine overdose. J Toxicol Clin Toxicol 199331493–496. - PubMed

Publication types