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Comment
. 2007 Jun;151(3):303-4.
doi: 10.1038/sj.bjp.0707229. Epub 2007 Mar 26.

The fatter the better? Perivascular adipose tissue attenuates vascular contraction through different mechanisms

R P Brandes  1
Affiliations
Comment

The fatter the better? Perivascular adipose tissue attenuates vascular contraction through different mechanisms

R P Brandes. Br J Pharmacol. 2007 Jun.

Abstract

Adipose tissue releases several hormones and autacoids and expansion of the adipose tissue and excessive obesity is a risk factor for hypertension. Perivascular adipose tissue, on the other hand, has been reported to lower the vascular tone through the release of a transferable, thermosensitive, non-lipid factor. In this issue of the British Journal of Pharmacology, Gao et al. (2007) report that a factor generated by the adipose tissue also stimulates the generation of NO by endothelium and that NO is the predominant mediator of adipose tissue-induced relaxation in endothelium-intact vessels.

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