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. 2007 Sep;254(9):1204-11.
doi: 10.1007/s00415-006-0501-8. Epub 2007 Mar 25.

Functioning of patients with chronic idiopathic axonal polyneuropathy (CIAP)

Peter G Erdmann  1 , Laurien L Teunissen, Frank R van Genderen, Nicolette C Notermans, Eline Lindeman, Paul J M Helders, Nico L U van Meeteren
Affiliations

Functioning of patients with chronic idiopathic axonal polyneuropathy (CIAP)

Peter G Erdmann et al. J Neurol. 2007 Sep.

Abstract

Although patients with Chronic Idiopathic Axonal Polyneuropathy (CIAP) report a slow deterioration of sensory and motor functions, the impact of this deterioration on daily functioning has not yet been investigated in detail. The first aim of this cross-sectional study involving 56 patients with CIAP was, therefore, to assess patients' functioning with use of the International Classification of Functioning, Disability and Health (ICF). The second aim was to find determinants of walking ability, dexterity, and autonomy. Fatigue and limited walking ability were present in most patients and differed considerably. In regression models, age, muscle strength, and fatigue together explained 63% of the variance in walking ability, which by itself explained almost 50% of the variance in patients' autonomy indoors and outdoors (42% and 49%, respectively). Muscle strength and sensory function scores together explained 30% of the variance in dexterity scores, which in turn explained only 13% of the variance in autonomy indoors. The diminished autonomy of patients with CIAP might be improved by reducing fatigue, by means of training, and by improving walking ability.

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Figures

Fig. 1
Fig. 1
Interactions between the components of the International Classification of Functioning, Disability and Health (ICF)
Fig. 2
Fig. 2
Linear regression analysis of associations between body functions, activities, and participation, for arm functioning (A) and leg functioning (B), after adjustment for age (A and B) and the use of walking aids (B). Interpretation (Figure 2A, box starting with 30%): analysis of the effect of independent body functions (represented by muscle strength, sensory function, and pain) on dependent activity (represented by dexterity), resulted in a model explaining a total of 30% (Adjusted R2 × 100) of the total variance in dexterity scores, when adjusted for age, with a significance of p < 0.01. Pain was eliminated as contributing variable in the stepwise procedure. The relative contribution of the independent variables is expressed as β, the standardized coefficient beta. βage, beta age; βms, beta muscle strength; βsf, beta sensory function; βd, beta dexterity; βwa, beta walking aids; βf, beta fatigue; βb, beta balance; βwp, beta walking performance. In Figure 2A, box 30%: when dexterity on the SODA is improved by 1 point, age is increased by −0.065 years, muscle strength is increased by 0.396 Z-score, and sensory function is increased by 0.335 points
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