Comment
doi: 10.1016/j.molcel.2007.03.006.
Mdm2: p53's lifesaver?
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- PMID: 17386256
- DOI: 10.1016/j.molcel.2007.03.006
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Comment
Mdm2: p53's lifesaver?
Mol Cell.
.
Free article
Abstract
In a recent issue of Molecular Cell, Taira et al. (2007) and Rinaldo et al. (2007) provide insight into the involvement of the DYRK2 kinase and a surprising role of MDM2 in regulation of DNA damage-induced apoptosis via p53 phosphorylation.
Comment on
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DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.Mol Cell. 2007 Mar 9;25(5):725-38. doi: 10.1016/j.molcel.2007.02.007. Mol Cell. 2007. PMID: 17349958
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MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.Mol Cell. 2007 Mar 9;25(5):739-50. doi: 10.1016/j.molcel.2007.02.008. Mol Cell. 2007. PMID: 17349959
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