Renal ischemia-reperfusion injury: renal dendritic cells loudly sound the alarm
- PMID: 17387309
- DOI: 10.1038/sj.ki.5002121
Renal ischemia-reperfusion injury: renal dendritic cells loudly sound the alarm
Abstract
Renal ischemia-reperfusion injury is a major cause of acute renal failure and kidney allograft dysfunction. Dong and colleagues now identify the surveying renal dendritic cell network as the predominant source of tumor necrosis factor-alpha during the early stages of renal ischemia-reperfusion injury, raising the possibility for direct targeting of renal dendritic cells to help ameliorate this common form of renal injury and its sequelae.
Comment on
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Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury.Kidney Int. 2007 Apr;71(7):619-28. doi: 10.1038/sj.ki.5002132. Epub 2007 Feb 21. Kidney Int. 2007. PMID: 17311071
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