Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jun;35(2):189-93.
doi: 10.1007/s11033-007-9069-3. Epub 2007 Mar 27.

Transcriptional inhibition by a non-histone protein from low mobility group in homologous and heterologous in vitro systems

Maryam Shahhoseini  1 , Azra Rabbani-Chadegani
Affiliations

Transcriptional inhibition by a non-histone protein from low mobility group in homologous and heterologous in vitro systems

Maryam Shahhoseini et al. Mol Biol Rep. 2008 Jun.

Abstract

An acidic non-histone chromosomal protein of low mobility group (LMG) with pI of 5-5.5 and molecular weight of 160 kDa (named LMG160), has been isolated from rat liver nuclei and its inhibitory effect on transcription of DNA in vitro has been detected in a heterologous prokaryotic in vitro transcription system (T7 RNA polymerase) and also confirmed in the homologous cell-free system of rat liver nuclear extract. The results indicate that in the presence of non-histone protein LMG160, in vitro RNA synthesis represses in the both systems, which can suggest a functional role for this non-histone chromosomal protein.

PubMed Disclaimer

References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Eur J Biochem. 1973 Dec 3;40(1):215-9 - PubMed
    1. Nucleic Acids Res. 2001 Mar 1;29(5):1047-53 - PubMed
    1. Mol Cell Biol. 1999 Aug;19(8):5237-46 - PubMed
    1. Biochem Biophys Res Commun. 1990 Jan 15;166(1):11-21 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources