Influence of liver's oxide-reductive homeostasis disorder for AKBR values in rabbit's arterial blood

Abstract

The keton bodies are created generally in a liver, but this organ has no enzymatic system able to metabolize them. A dependence exists between the molar acetoacetate concentration and the molar beta-hydroxybutyrate concentration, and it can be an indicator of quantitive relations between NAD and NADH. Metabolic reserve can be estimated on the basis of the molar concentration of keton bodies in the arterial blood--of the AKBR value. Tests were carried out on specially prepared rabbit arterial blood samples. Because there is no way to measure NAD to NADH cocentrations in the liver directly a relationship between acetoacetate and beta-hydroxybutarate serves to estimate of the oxydo-reductive status of this key organ. That is why AKBR values seem to be extremely important. Vitamin E is known for it's cytoprotective influence of hepatic cells damage. In the presented paper we've challenged this hypothesis by analysing of correlation between AKBR values in examined rabbit groups.