Clinical xenotransplantation of organs: why aren't we there yet?
- PMID: 17388658
- PMCID: PMC1831726
- DOI: 10.1371/journal.pmed.0040075
Clinical xenotransplantation of organs: why aren't we there yet?
Abstract
Mohiuddin discusses the lessons learned from large animal xenograft models and why the immunological barrier is still the most important hurdle preventing clinical xenotransplantation of organs.
Conflict of interest statement
Figures
References
-
- Ohdan H, Swenson KG, Kitamura H, Yang YG, Sykes M. Tolerization of Gal alpha 1,3Gal-reactive B cells in pre-sensitized alpha 1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. Xenotransplantation. 2001;8:227–238. - PubMed
-
- Ohdan H, Yang YG, Swenson KG, Kitamura H, Sykes M. T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. Transplantation. 2001;71:1532–1542. - PubMed
-
- Mohiuddin MM, Ogawa H, Yin DP, Galili U. Tolerance induction to a mammalian blood group-like carbohydrate antigen by syngeneic lymphocytes expressing the antigen, II: tolerance induction on memory B cells. Blood. 2003;102:229–236. - PubMed
-
- Mohiuddin MM, Ogawa H, Yin DP, Shen J, Galili U. Antibody-mediated accommodation of heart grafts expressing an incompatible carbohydrate antigen. Transplantation. 2003;75:258–262. - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical