Do CD4+ T cell functional responses to Epstein-Barr virus provide protective immunity against CNS lymphoma in AIDS?
- PMID: 17388670
- PMCID: PMC1831741
- DOI: 10.1371/journal.pmed.0040110
Do CD4+ T cell functional responses to Epstein-Barr virus provide protective immunity against CNS lymphoma in AIDS?
Abstract
Jacobson discusses a new study addressing the question of whether an EBV antigen-specific T cell response might be a critical component of protective immunity that is lost as part of the pathogenesis of AIDS-related primary CNS lymphoma.
Conflict of interest statement
Comment in
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HIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts.PLoS Med. 2007 Mar 27;4(3):e96. doi: 10.1371/journal.pmed.0040096. PLoS Med. 2007. PMID: 17388662 Free PMC article.
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