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. 1975 Jan;17(1):247-53.
doi: 10.1128/JVI.17.1.247-253.1976.

Transformation of hamster kidney cells by BK papovavirus DNA

K K Takemoto, M A Martin

Transformation of hamster kidney cells by BK papovavirus DNA

K K Takemoto et al. J Virol. 1975 Jan.

Abstract

Supercoiled BK papovavirus DNA was shown to transform hamster kidney cells using the calcium phosphate co-precipitation technique. The transformed cells contained intranuclear T-antigen(s) and rescuable virus and produced progressively growing tumors when inoculated into hamsters. A novel finding was the production in tumor-bearing animals of antinuclear antibody, which reacted against normal, untransformed cells; in addition, tumor serum contained antibody against virus-specific T-antigen(s).

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