doi: 10.1128/JVI.17.1.247-253.1976.
Transformation of hamster kidney cells by BK papovavirus DNA
- PMID: 173887
- PMCID: PMC515409
- DOI: 10.1128/JVI.17.1.247-253.1976
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Transformation of hamster kidney cells by BK papovavirus DNA
J Virol.
1975 Jan.
Abstract
Supercoiled BK papovavirus DNA was shown to transform hamster kidney cells using the calcium phosphate co-precipitation technique. The transformed cells contained intranuclear T-antigen(s) and rescuable virus and produced progressively growing tumors when inoculated into hamsters. A novel finding was the production in tumor-bearing animals of antinuclear antibody, which reacted against normal, untransformed cells; in addition, tumor serum contained antibody against virus-specific T-antigen(s).
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