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Review
. 2007 Apr;17(2):131-40.
doi: 10.1016/j.semradonc.2006.11.009.

Normal tissue tolerance dose metrics for radiation therapy of major organs

Michael T Milano  1 , Louis S Constine, Paul Okunieff
Affiliations
Review

Normal tissue tolerance dose metrics for radiation therapy of major organs

Michael T Milano et al. Semin Radiat Oncol. 2007 Apr.

Abstract

Late organ toxicity from therapeutic radiation is a function of many confounding variables. The total dose delivered to the organ and the volumes of organ exposed to a given dose of radiation are 2 important variables that can be used to predict the risk of late toxicity. Three-dimensional radiation planning enables accurate calculation of the volume of tissue exposed to a given dose of radiation, graphically depicted as a dose-volume histogram. Dose metrics obtained from this 3-dimensional dataset can be used as a quantitative measure to predict late toxicity. This review summarizes the published clinical data on the risk of late toxicity as a function of quantitative dose metrics and attempts to offer suggested dose constraints for radiation treatment planning.

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