[The regulatory role of mitochondrial dysfunction in hypoxia and its interaction with transcription activity]

Abstract

The mitochondrial respiratory chain participates in the performance of the signal system, which activates the realization of metabolic compensatory processes and coupled functional response to both single and repeated, long-term exposure to acute hypoxia. Under the conditions of reduced oxygen delivery to cells the mitochondrial respiratory chain is involved in the process of oxygen homeostasis regulation and modulates oxygen consumption, the rate of oxygen delivery from the extracellular milieu to mitochondria, and energy synthesis, activating hypoxia-specific transcription factors as well.