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. 2007 May-Jun;9(3):437-45.
doi: 10.1021/cc0601332. Epub 2007 Mar 31.

Parallel synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library

Dyeison Antonow  1 , Nectaroula Cooper, Philip W Howard, David E Thurston
Affiliations

Parallel synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library

Dyeison Antonow et al. J Comb Chem. 2007 May-Jun.

Abstract

A 66-member C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library has been successfully synthesized in parallel via Suzuki coupling using PS-PPh3Pd (catalyst) and PS-DEAM (scavenger) under microwave radiation. Library members were obtained in sufficient yield (up to 91%) and purity (85-98% crude) for biological evaluation.

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