Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jan;50(1):80-7.
doi: 10.1007/BF00297302.

Production of new trabecular bone in osteopenic ovariectomized rats by prostaglandin E2

S Mori  1 , W S Jee, X J Li
Collaborators, Affiliations

Production of new trabecular bone in osteopenic ovariectomized rats by prostaglandin E2

S Mori et al. Calcif Tissue Int. 1992 Jan.

Abstract

Serum chemistry and bone morphometry of the proximal tibial metaphysis were performed in 3-month-old double fluorescent-labeled, female Sprague-Dawley rats subjected to bilateral ovariectomy or sham surgery for 4 months prior to treatment with 0, 0.3, 1, 3, or 6 mg of prostaglandin E2 (PGE2)/kg/day subcutaneously for 30 days. The 4-month postovariectomized rats possessed an osteopenic proximal tibial metaphysis with 7% trabecular area compared with controls (19%). PGE2 treatment elevated osteocalcin levels and augmented proximal tibial metaphyseal bone area in ovariectomized and sham-operated rats. Osteopenic, ovariectomized rats treated with 6 mg PGE2/kg/day for 30 days restored bone area to levels of age-matched sham-operated rats. Morphometric analyses showed increased woven and lamellar bone area, fluorescent-labeled perimeter (osteoblastic recruitment), mineral apposition rate (osteoblastic activity), bone formation rate (BFR/BV), and longitudinal bone growth. These dramatic bone changes were all significantly increased at the dose-response manner. This study showed that in vivo PGE2 is a powerful activator of bone remodeling, it increases both bone resorption and bone formation, and produces an anabolic effect by shifting bone balance to the positive direction. Furthermore, PGE2-induced augmentation of metaphyseal bone area in ovariectomized rats was at least two times greater than in sham-operated rats.

PubMed Disclaimer

References

    1. J Bone Miner Res. 1986 Feb;1(1):15-21 - PubMed
    1. Bone. 1990;11(4):253-66 - PubMed
    1. Calcif Tissue Int. 1985 Mar;37(2):148-57 - PubMed
    1. Calcif Tissue Int. 1988 Sep;43(3):179-83 - PubMed
    1. Anat Rec. 1986 Jul;215(3):305-16 - PubMed

Publication types

MeSH terms