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. 2007 Apr;68(8):1172-8.
doi: 10.1016/j.phytochem.2007.02.021. Epub 2007 Mar 30.

Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii

Jun Ma  1 , Moul Dey, Hui Yang, Alexander Poulev, Reneta Pouleva, Ruth Dorn, Peter E Lipsky, Edward J Kennelly, Ilya Raskin
Affiliations

Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii

Jun Ma et al. Phytochemistry. 2007 Apr.

Abstract

The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide.

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