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. 2007;114(8):1065-8.
doi: 10.1007/s00702-007-0705-9. Epub 2007 Mar 31.

Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression

S Anttila  1 , K Huuhka, M Huuhka, R Rontu, M Hurme, E Leinonen, T Lehtimäki
Affiliations

Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression

S Anttila et al. J Neural Transm (Vienna). 2007.

Abstract

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.

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