Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007;114(8):1065-8.
doi: 10.1007/s00702-007-0705-9. Epub 2007 Mar 31.

Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression

S Anttila  1 , K Huuhka, M Huuhka, R Rontu, M Hurme, E Leinonen, T Lehtimäki
Affiliations

Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression

S Anttila et al. J Neural Transm (Vienna). 2007.

Abstract

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J ECT. 2005 Mar;21(1):7-11 - PubMed
    1. Biol Psychiatry. 2006 Jun 15;59(12):1116-27 - PubMed
    1. Neuropsychopharmacology. 2005 Jul;30(7):1353-61 - PubMed
    1. Science. 2003 Jul 18;301(5631):386-9 - PubMed
    1. Biol Psychiatry. 2006 Jan 15;59(2):106-13 - PubMed

Publication types

MeSH terms

LinkOut - more resources