TOR and aging: less is more
- PMID: 17403368
- DOI: 10.1016/j.cmet.2007.03.005
TOR and aging: less is more
Abstract
Metabolism and mitochondrial activity are thought to be important determinants of life span. A new study in this issue of Cell Metabolism (Bonawitz et al., 2007) suggests that the TOR pathway controls mitochondrial respiration in yeast and that the harder mitochondria work, the longer yeast live.
Comment on
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Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression.Cell Metab. 2007 Apr;5(4):265-77. doi: 10.1016/j.cmet.2007.02.009. Cell Metab. 2007. PMID: 17403371 Free PMC article.
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