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Review
. 2007 Mar;12(3):325-30.
doi: 10.1634/theoncologist.12-3-325.

Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer

Lecia V Sequist  1
Affiliations
Free article
Review

Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer

Lecia V Sequist. Oncologist. 2007 Mar.
Free article

Abstract

Inhibiting epidermal growth factor receptor (EGFR) signaling has proven to be an effective strategy for treating non-small cell lung cancer (NSCLC) patients and the first generation of agents developed for this purpose, gefitinib and erlotinib, stimulated a unique escalation in both biologic and clinical research within the field. Second-generation EGFR-targeted agents that aim to further improve patient outcomes are now in preclinical and clinical trials. This review discusses four promising agents that are currently being studied in NSCLC: EKB-569, HKI-272, CI-1033, and ZD6474.

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