Review
doi: 10.1002/eji.200636933.
GITR/GITRL: more than an effector T cell co-stimulatory system
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- PMID: 17407102
- DOI: 10.1002/eji.200636933
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Review
GITR/GITRL: more than an effector T cell co-stimulatory system
Eur J Immunol.
2007 May.
Free article
Abstract
Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily, expressed in several cells and tissues including T lymphocytes, NK cells and antigen-presenting cells (APC). GITR activation, upon interaction with its ligand (GITRL), functions as a co-activating signal. GITRL is mainly expressed on APC and GITR/GITRL interaction is important for the development of immune response. This review summarizes recent results about the GITR/GITRL system, focusing on the interplay between APC, effector and regulatory T cells.
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