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Review
. 2007 May;37(5):1165-9.
doi: 10.1002/eji.200636933.

GITR/GITRL: more than an effector T cell co-stimulatory system

Giuseppe Nocentini  1 , Simona Ronchetti, Salvatore Cuzzocrea, Carlo Riccardi
Affiliations
Free article
Review

GITR/GITRL: more than an effector T cell co-stimulatory system

Giuseppe Nocentini et al. Eur J Immunol. 2007 May.
Free article

Abstract

Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily, expressed in several cells and tissues including T lymphocytes, NK cells and antigen-presenting cells (APC). GITR activation, upon interaction with its ligand (GITRL), functions as a co-activating signal. GITRL is mainly expressed on APC and GITR/GITRL interaction is important for the development of immune response. This review summarizes recent results about the GITR/GITRL system, focusing on the interplay between APC, effector and regulatory T cells.

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