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Review
. 2007 Apr;6(2):213-26.
doi: 10.1586/14760584.6.2.213.

Pulmonary vaccine delivery

Dongmei Lu  1 , Anthony J Hickey
Affiliations
Review

Pulmonary vaccine delivery

Dongmei Lu et al. Expert Rev Vaccines. 2007 Apr.

Abstract

This review will discuss developments in the field of pulmonary vaccine delivery. The possibilities of adopting aerosol-generation technology and specific pharmaceutical formulations for the purpose of pulmonary immunization are described. Aerosol-generation systems might offer advantages with respect to vaccine stability and antigenicity. Adjuvants and their inclusion in vaccine-delivery systems are described. Other formulation components, such as surfactants, particulate systems and dispersion of the aerosols are detailed in this paper. The noninvasive, relatively safe and low-cost nature of pulmonary delivery may provide great benefits to the public health vaccination campaign.

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