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. 1975 Dec;72(12):4991-3.
doi: 10.1073/pnas.72.12.4991.

Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum

J M Mato, A Losada, V Nanjundiah, T M Konijn

Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum

J M Mato et al. Proc Natl Acad Sci U S A. 1975 Dec.

Abstract

Drops with different concentrations of 3':5'-cyclic AMP were deposited at various distances from small populations of Dictyostelium discoideum amoebae, and the distances over which 50% of the amoebae drops reacted positively were determined. The linear regression analysis of a bouble logarithmic plot of distance against concentration gives a straight line with a slope of 1/4.25, which value suggests that the amoebae respond to a spatial gradient of cyclic AMP concentration. The threshold value for the signal is 3.6 X 10(-9) M/mm with a sensitivity of measurement of about 1%. These findings are discussed in relation to our present knowledge of cyclic AMP receptors.

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