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. 2007 Jun;45(6):1965-8.
doi: 10.1128/JCM.00261-07. Epub 2007 Apr 4.

Addition of neuA, the gene encoding N-acylneuraminate cytidylyl transferase, increases the discriminatory ability of the consensus sequence-based scheme for typing Legionella pneumophila serogroup 1 strains

Sandra Ratzow  1 , Valeria Gaia, Jürgen Herbert Helbig, Norman K Fry, Paul Christian Lück
Affiliations

Addition of neuA, the gene encoding N-acylneuraminate cytidylyl transferase, increases the discriminatory ability of the consensus sequence-based scheme for typing Legionella pneumophila serogroup 1 strains

Sandra Ratzow et al. J Clin Microbiol. 2007 Jun.

Abstract

The standard sequence-based method for the typing of Legionella pneumophila serogroup 1 strains was extended by using the gspA and neuA alleles. The use of neuA as a seventh allele for typing significantly increased the index of discrimination calculated for a panel of unrelated strains (from 0.932 to 0.963) and subdivided some known large common complexes (e.g., 1,4,3,1,1,1). This modification to the standard method is proposed as the method of choice in the epidemiological investigation of L. pneumophila infections.

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