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. 2007 Sep;84(3):249-53.
doi: 10.1007/s11060-007-9378-3. Epub 2007 Apr 5.

Association of telomerase gene hTERT polymorphism and malignant gliomas

Catherine Carpentier  1 , Julie Lejeune, Florent Gros, Sibille Everhard, Yannick Marie, Gentian Kaloshi, Florence Laigle-Donadey, Khe Hoang-Xuan, Jean-Yves Delattre, Marc Sanson
Affiliations

Association of telomerase gene hTERT polymorphism and malignant gliomas

Catherine Carpentier et al. J Neurooncol. 2007 Sep.

Abstract

Background: The MNS16A polymorphism is located in the downstream region of the hTERT gene and affects telomerase activity.

Methods: MNS16A has been investigated as a potential risk factor and/or prognostic marker for malignant glioma in a cohort of 352 patients (205 glioblastoma, 147 anaplastic gliomas) and 305 controls.

Results: The S ("short") allele (which results in a higher telomerase activity) was significantly more frequent in glioma patients compared to the control population (278/704=39.5% vs. 200/610=32.8%; P=0.012). The odd ratios were 1 for LL (taken as reference), 1.33 [0.96; 1.84] for SL and 2.05 [1.22; 3.44] for SS. However, in contrast to a previous report, no significant difference of survival was found between SS, LL and SL allelotypes.

Conclusion: We found here the short allele of MNS16A more frequent in glioma patients, but it did not seem to be predictive of survival.

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