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Review
. 2008 Mar;86(3):457-8.
doi: 10.1016/j.exer.2007.01.025. Epub 2007 Feb 16.

Focus on molecules: lacritin

Peisong Ma  1 , Ningning Wang, Robert L McKown, Ronald W Raab, Gordon W Laurie
Affiliations
Review

Focus on molecules: lacritin

Peisong Ma et al. Exp Eye Res. 2008 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Structural features of lacritin. A. Linear model of lacritin from human and nonhuman primates showing alignment of PSIPRED-predicted α-helices (Wang et al, ’06) including the SP, regions of PONDR-predicted ‘disorder’ (dashed boxes), suggested post-translational O-linked (green pegs; NetOGlyc 3.1) and N-linked (purple peg; SeqWeb, PeptideStructure) glycosylation on human lacritin, lacritin-b and lacritin-c alternative splice forms, and the SDC1 binding domain (Ma et al., ’2006). B. VDW structural model (VMD) based on weak tertiary structure alignment to PDB structure 1usp B (tertiary prediction score 1.1; SamT02) by the GeneSilico Metaserver.
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References

    1. Ma P, Beck SL, Raab RW, McKown RL, Coffman GL, Utani A, Chirico WJ, Rapraeger AC, Laurie GW. Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. J. Cell Biol. 2006;74:1097–1106. - PMC - PubMed
    1. Sanghi S, Kumar R, Lumsden A, Dickinson D, Klepeis V, Trinkaus-Randall V, Frierson HF, Jr, Laurie GW. cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. J. Mol. Biol. 2001;310:127–139. - PubMed
    1. Tsai PS, Evans JE, Green KM, Sullivan RM, Schaumberg DA, Richards SM, Dana MR, Sullivan DA. Proteomic analysis of human meibomian gland secretions. Br. J. Ophthalmol. 2006;90:372–377. - PMC - PubMed
    1. Wang J, Wang N, Xie J, Walton SC, McKown RL, Raab RW, Ma P, Beck SL, Coffman GL, Hussaini IM, Laurie GW. Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. J Cell Biol. 2006;174:689–700. - PMC - PubMed

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