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. 1992 Feb 11;20(3):507-11.
doi: 10.1093/nar/20.3.507.

Formation of novel hairpin structures by telomeric C-strand oligonucleotides

S Ahmed  1 , E Henderson
Affiliations
Free PMC article

Formation of novel hairpin structures by telomeric C-strand oligonucleotides

S Ahmed et al. Nucleic Acids Res. .
Free PMC article

Abstract

Telomeres are specialized structures at the ends of chromosomes that are required for long term chromosome stability and replication of the chromosomal terminus. Telomeric DNA consists of simple repetitive sequences with one strand G-rich relative to the other, C-rich, strand. Evolutionary conservation of this feature of telomeric repeat sequences suggests that they have specific structural characteristics involved in telomere function. Absorbance thermal denaturation, chemical modification and non-denaturing gel electrophoretic analyses showed that telomeric C-strand oligonucleotides form stable non-Watson-Crick hairpin structures containing C.C+ base pairs. Formation of such hairpins may facilitate previously reported G-strand exclusive interactions.

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References

    1. Biochemistry. 1991 May 7;30(18):4460-72 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 Feb;87(3):867-70 - PubMed
    1. Nature. 1991 Apr 18;350(6319):569-73 - PubMed
    1. Nucleic Acids Res. 1991 Jun 25;19(12):3409-19 - PubMed
    1. Nature. 1991 Apr 25;350(6320):718-20 - PubMed

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