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Comparative Study
. 2007 Jul;44(7):445-7.
doi: 10.1136/jmg.2007.050070. Epub 2007 Apr 5.

Attenuated aerobic exercise capacity in CD36 deficiency

Hidekatsu Yanai  1 , Ichiro Watanabe, Kojiro Ishii, Mie Morimoto, Hironobu Fujiwara, Shigeru Yoshida, Shu-Ping Hui, Kazuhiko Matsuno, Hitoshi Chiba
Affiliations
Comparative Study

Attenuated aerobic exercise capacity in CD36 deficiency

Hidekatsu Yanai et al. J Med Genet. 2007 Jul.

Abstract

Background: An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT). We studied whether aerobic exercise capacity in humans could be affected by CD36 deficiency.

Methods: We investigated the ventilatory threshold (VT) and serum FA changes in normal participants (n = 22) and participants with CD36 deficiency (n = 12) during pedalling on a cycle ergometer.

Results: In participants with CD36 deficiency, FA levels were not reduced at peak work rate, whereas FA levels decreased by about 50% in normal participants. Participants with CD36 deficiency showed significantly lower VT than normal participants. A significant correlation was observed between VT and percentage changes in FA at peak work rate.

Conclusion: This study found reduced FA utilisation and an attenuated aerobic exercise capacity in CD36 deficiency, indicating that CD36-mediated FA oxidation is an important determinant for aerobic exercise capacity in humans.

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Conflict of interest statement

Competing interests: None declared.

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