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. 2007 May;61(5 Pt 1):546-51.
doi: 10.1203/pdr.0b013e318045be99.

Assessment of infant brain development with frequency-domain near-infrared spectroscopy

Maria Angela Franceschini  1 , Sonal Thaker, George Themelis, Kalpathy K Krishnamoorthy, Heather Bortfeld, Solomon G Diamond, David A Boas, Kara Arvin, P Ellen Grant
Affiliations

Assessment of infant brain development with frequency-domain near-infrared spectroscopy

Maria Angela Franceschini et al. Pediatr Res. 2007 May.

Abstract

This is the first report to demonstrate quantitative monitoring of infant brain development with frequency-domain near-infrared spectroscopy (FD-NIRS). Regionally specific increases in blood volume and oxygen consumption were measured in healthy infants during their first year. The results agree with prior PET and SPECT reports; but, unlike these methods, FD-NIRS is portable and uses nonionizing radiation. Further, new information includes the relatively constant tissue oxygenation with age and location, suggesting a tight control between local oxygen delivery and consumption in healthy infants during brain development. FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development.

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Figures

Figure 1
Figure 1
(a) Probe positions and (b) Measurement of an infant.
Figure 2
Figure 2
Linear per week changes in HbT (top), CBV (middle) and StO2 (bottom) from 0 to 50 weeks in six brain regions. * indicate P<0.05. The error bars are standard deviations. The numbers of subjects for the 6 locations are: 35, 35, 38, 43, 38, 39.
Figure 3
Figure 3
From top to bottom: HbT, CBV, and StO2 as a function of age measured in the frontal region in all infants. The straight lines are the linear regressions from 0 to 6 wks, 12 to 50 wks, and 0 to 50 wks. The empty circles correspond to premature babies. The cyan circles are the results for a baby measured longitudinally 20 times from 0 to 11 months. Y and R2 for each regression line are reported on the graphs with the same color as the regression line.
Figure 4
Figure 4
CBV, and StO2 for 6 age groups in the 6 brain regions. Magenta vertical arrows indicate P < 0.05. Error bars are standard errors between infants. The number of infants in each age group is: 6, 8, 6, 7, 3, and 8, respectively.
See this image and copyright information in PMC

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