Pulmonary hypertension, hyperthyroidism, and fenfluramine: a case report and review
- PMID: 17415311
- PMCID: PMC1868350
Pulmonary hypertension, hyperthyroidism, and fenfluramine: a case report and review
Abstract
We report a case of pulmonary hypertension presenting with sudden cardiac arrest, hyperthyroidism and fenfluramine usage. This fatal case of pulmonary hypertension and valvular heart disease is associated with the use of an anorectic drug that had been withdrawn from the market more than eight years ago. Clinicians should alert to the side effects of appetite suppressant and slimming agents. The association between pulmonary hypertension in relation to hyperthyroidism and fenfluramine usage is reviewed.
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References
-
- Gaine SP, Rubin LJ. Primary pulmonary hypertension. Lancet. 1998;352:719–725. - PubMed
-
- Simonneau G, Galie N, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2004;43(12 Suppl S):5S–12S. - PubMed
-
- Simonneau G, Fartoukh M, Sitbon O, Humbert M, Jagot JL, Herve P. Primary pulmonary hypertension associated with the use of fenfluramine derivatives. Chest. 1998;114:195–199S. - PubMed
-
- Weir EK, Reeve HL, Huang JM, Michelakis E, Nelson DP, Hampl V, et al. Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation. 1997;94:2216–2220. - PubMed
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