Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Nov 8;8(4):29.

Pulmonary hypertension, hyperthyroidism, and fenfluramine: a case report and review

Ying Ying Leung  1 , Kam Shing Tang, Chiu Chi Tsang, Chi Kin Chan, Kwan Keung Wong, Alex Wai-yin Yu
Affiliations
Review

Pulmonary hypertension, hyperthyroidism, and fenfluramine: a case report and review

Ying Ying Leung et al. MedGenMed. .

Abstract

We report a case of pulmonary hypertension presenting with sudden cardiac arrest, hyperthyroidism and fenfluramine usage. This fatal case of pulmonary hypertension and valvular heart disease is associated with the use of an anorectic drug that had been withdrawn from the market more than eight years ago. Clinicians should alert to the side effects of appetite suppressant and slimming agents. The association between pulmonary hypertension in relation to hyperthyroidism and fenfluramine usage is reviewed.

PubMed Disclaimer

References

    1. Gaine SP, Rubin LJ. Primary pulmonary hypertension. Lancet. 1998;352:719–725. - PubMed
    1. Simonneau G, Galie N, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2004;43(12 Suppl S):5S–12S. - PubMed
    1. Simonneau G, Fartoukh M, Sitbon O, Humbert M, Jagot JL, Herve P. Primary pulmonary hypertension associated with the use of fenfluramine derivatives. Chest. 1998;114:195–199S. - PubMed
    1. Weir EK, Reeve HL, Huang JM, Michelakis E, Nelson DP, Hampl V, et al. Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation. 1997;94:2216–2220. - PubMed
    1. Brenot F, Herve P, Petitpretz P, Parent F, Duroux P, Simonneau G. Primary pulmonary hypertension and fenfluramine use. Br Heart J. 1993;70:537–541. - PMC - PubMed

LinkOut - more resources